Refer to the scenario to answer #3. The cancer cells in nea
Refer to the scenario to answer #3. The cancer cells in nearly all… Refer to the scenario to answer #3. The cancer cells in nearly all patients with chronic myelogenous leukemia (CML) contain an abnormally short chromosome 22, called the Philadelphia chromosome and an abnormally long chromosome 9. This is caused by the reciprocal translocation of segments of chromosome between the two chromosomes. The alteration of the chromosome occurred in a single white blood cell precursor undergoing mitosis and was passed on to all descendant cells. The gene that is activated on the Philadelphia chromosome codes for an intracellular tyrosine kinase. 3. Use what you know about cell cycle controls to explain how the activation of this gene could contribute to the development of cancer. Science Biology BSC 2010
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