In this unit, we discussed the Invasion-Metastasis Cascade.

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In this unit, we discussed the Invasion-Metastasis Cascade. The… In this unit, we discussed the Invasion-Metastasis Cascade. The paper isPienta, Kenneth J et al. “The cancer diaspora: Metastasis beyond the seed and soil hypothesis.” Clinical cancer research: an official journal of the American Association for Cancer Research vol. 19,21 (2013): 5849-55. doi:10.1158/1078-0432.CCR-13-2158Read the paper and answer the following questions. 1. According to the authors, what are the steps or processes involved in Migration?2. The authors use “diaspora” to describe metastatic cells. What is a diaspora and what are the characteristics of “diaspora” that the authors identify in comparing cancer cells to this term usually applied to populations of people?3. What are the 3 factors listed by the author that can affect the “rate” at which a diaspora of cancer cells is established?4. How do the authors apply ecological principles in suggesting treatment regimens to deal with metastatic cancer? What are 2 ecology mechanisms the authors suggest that might be used to treat cancer?Science Biology

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